Integrin β4 in Breast Cancer: A Focused Review

Zoya Salahuddin, Shuhan Ying, Emily Xie, Aizhang Xu, Xiaojing Ma

Abstract: Integrin β4 (ITGB4) is emerging as a pivotal player in breast cancer progression, particularly in aggressive and invasive subtypes such as triple-negative breast cancer (TNBC). This review broadly summarizes current research on ITGB4’s involvement in breast cancer, focusing on its role in metastasis, metabolic reprogramming, drug resistance, and immunoregulation that collectively influence tumor behavior with implications for the development of innovative and more efficacious therapeutic modalities.