Genome-wide perturbations of A-to-I RNA editing dysregulated circular RNAs promoting the development of cervical cancer

Yulan Wang, Jian Zhao, Jing Wu, Jingjing Liu, Yixuan Wang, Tianyi Xu, Meng Zhang, Minhui Zhuang, Lingxiao Zou, Wei Sun, Ping Han, Xiaofeng Song

Abstract: Highlights•An exhaustive analysis of dysregulated circular RNAs relevant to RNA editing in cervical cancer was performed.•RNA editing sites (RESs) are symmetrically enriched upstream and downstream of flanking introns of circRNAs.•The coding potential of circRNAs appears to be attenuated by RNA editing.•RESs disrupted regulatory cascades by modifying RBP or miRNA binding sites in circRNA.•Three RNA editing sites could be identified as potential biomarkers for cervical cancer.