Toward a Coherent Virtual Cell Model: Probing Biological World-Model Coherence in Transcriptomic Foundation Models

Noa Moriel, Yishai Shimoni, Michal Rosen-Zvi, Michael Danziger

Published: 23 Sept 2025, Last Modified: 17 Oct 2025AI4D3 2025 PosterEveryoneRevisionsBibTeXCC BY 4.0
Keywords: transcriptomic foundation models, scrna, transcriptomics, virtual cell models, world model
TL;DR: We propose a zero-resource model agnostic method for evaluating the internal coherence of a transcriptomic foundation model, based on synthetic samples and pretraining loss evaluation.
Submission Number: 26