Gene regulation inference from single-cell RNA-seq data with linear differential equations and velocity inference

Pierre-Cyril Aubin-Frankowski, Jean-Philippe Vert

Abstract: Single-cell RNA sequencing (scRNA-seq) offers new possibilities to infer gene regulatory network (GRNs) for biological processes involving a notion of time, such as cell differentiation or cell cycles. It also raises many challenges due to the destructive measurements inherent to the technology.