Towards quantitative intensity analysis of conventional T1-weighted images in multiple sclerosis

Tun Wiltgen, Julian McGinnis, Ronja C. Berg, Cui Ci Voon, Oula Puonti, Katrin Giglhuber, Carl Ganter, Claus Zimmer, Bernhard Hemmer, Benedikt Wiestler, Jan Kirschke, Christine Preibisch, Mark Mühlau

Abstract: Highlights•Temporal fatty tissue as a reference region for retrospective T1w MRI intensity scaling.•High correlation of intensity-scaled T1w images with quantitative R1 maps.•Lower mean R1 values and fat-scaled T1w intensities in NAWM of patients with high EDSS.•NAWM intensity variability in bias-corrected T1w images increases with MS disease severity.•Conventional T1w MRI intensities comprise exploitable information on MS pathology.

External IDs:dblp:journals/neuroimage/WiltgenMBVPGGZHWKPM25