Ensemble Tractography

Hiromasa Takemura, Cesar F. Caiafa, Brian A. Wandell, Franco Pestilli

Abstract: Author Summary Diffusion MRI and tractography opened a new avenue for studying white matter fascicles and their tissue properties in the living human brain. There are many different tractography methods, and each requires the user to set several parameters. A limitation of tractography is that the results depend on the selection of algorithms and parameters. Here, we analyze an ensemble method, Ensemble Tractography (ET), that reduces the effect of algorithm and parameter selection. ET creates a large set of candidate streamlines using an ensemble of algorithms and parameter values and then selects the streamlines with strong support from the data using a global fascicle evaluation method. Compared to single parameter connectomes, ET connectomes predict diffusion MRI signals better and cover a wider range of white matter volume. Importantly, ET connectomes include both short- and long-association fascicles, which are not typically found together in single-parameter connectomes.