Benchmarking Deep Learning Models for Predicting Anticancer Drug Potency (IC50): Insights for the Medicinal Chemist

Utpal Garain, Udbhas Garai, Aditya Pal, Koyel Ghosh, Deepak Salunke

Abstract: Potency (IC50) prediction of anticancer small molecules plays a vital role in developing drug candidates. Five deep learning models for IC50 prediction--DeepCDR, DrugCell, PaccMann, Precily, and tCNN--were benchmarked using standardized GDSC datasets and recently published a...

External IDs:doi:10.21203/rs.3.rs-7023097/v1