Inter-species prediction of protein phosphorylation in the sbv IMPROVER species translation challenge

Michael Biehl, Peter J. Sadowski, Gyan Bhanot, Erhan Bilal, Adel Dayarian, Pablo Meyer, Raquel Norel, Kahn Rhrissorrakrai, Michael D. Zeller, Sahand Hormoz

Abstract: : Animal models are widely used in biomedical research for reasons ranging from practical to ethical. An important issue is whether rodent models are predictive of human biology. This has been addressed recently in the framework of a series of challenges designed by the systems biology verification for Industrial Methodology for Process Verification in Research (sbv IMPROVER) initiative. In particular, one of the sub-challenges was devoted to the prediction of protein phosphorylation responses in human bronchial epithelial cells, exposed to a number of different chemical stimuli, given the responses in rat bronchial epithelial cells. Participating teams were asked to make inter-species predictions on the basis of available training examples, comprising transcriptomics and phosphoproteomics data.