Reformulating patient stratification for targeting interventions by accounting for severity of downstream outcomes resulting from disease onset: a case study in sepsis

Fahad Kamran, Donna Tjandra, Thomas S. Valley, Hallie C. Prescott, Nigam H. Shah, Vincent X. Liu, Eric Horvitz, Jenna Wiens

Abstract: To quantify differences between (1) stratifying patients by predicted disease onset risk alone and (2) stratifying by predicted disease onset risk and severity of downstream outcomes. We perform a case study of predicting sepsis.