An iteration model for identifying essential proteins by combining comprehensive PPI network with biological information

Shiyuan Li, Zhen Zhang, Xueyong Li, Yihong Tan, Lei Wang, Zhiping Chen

Abstract: Essential proteins have great impacts on cell survival and development, and played important roles in disease analysis and new drug design. However, since it is inefficient and costly to identify essential proteins by using biological experiments, then there is an urgent need for automated and accurate detection methods. In recent years, the recognition of essential proteins in protein interaction networks (PPI) has become a research hotspot, and many computational models for predicting essential proteins have been proposed successively.

External IDs:dblp:journals/bmcbi/LiZLTWC21