TopoTxR: A topology-guided deep convolutional network for breast parenchyma learning on DCE-MRIs

Fan Wang, Zhilin Zou, Nicole Sakla, Luke Partyka, Nil Rawal, Gagandeep Singh, Wei Zhao, Haibin Ling, Chuan Huang, Prateek Prasanna, Chao Chen

Abstract: Highlights•A deep network for breast tissue parenchyma analysis in DCE-MRIs.•Fibroglandular tissue approximated using topological structures.•Introduction of a novel topology-guided spatial attention mechanism.•Thorough evaluation on synthetic, I-SPY 1, and proprietary datasets.•Attention visualization demonstrating the model’s focus on fibroglandular tissue.