Emulate randomized clinical trials using heterogeneous treatment effect estimation for personalized treatments: Methodology review and benchmark

Yaobin Ling, Pulakesh Upadhyaya, Luyao Chen, Xiaoqian Jiang, Yejin Kim

Abstract: Highlights•Heterogeneous treatment effect (HTE) models estimate the individual treatment effect.•Compare HTE models in terms of handling treatment assignment and selection bias.•Perform benchmark experiments by emulating clinical trials with insurance claim data.•Discuss lessons learned, future research direction, opportunity, and limitations.