DN-ODE: Data-driven neural-ODE modeling for breast cancer tumor dynamics and progression-free survivals

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Jinlin Xiang, Bozhao Qi, Marc Cerou, Wei Zhao, Qi Tang

Published: 01 Jan 2024, Last Modified: 15 May 2025Comput. Biol. Medicine 2024EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•An individual breast cancer pharmacodynamics model using neural ODEs.•DN-ODE is trained on phase 1/2 Amcenestrant clinical trials and tested on phase 3.•DN-ODE employs a shared encoder and predicts tumor size and PFS from initial status.•DN-ODE decodes tumor dynamics and offers interpretable results and visualizations.