Hyperedge Representations with Hypergraph Wavelets: Applications to Spatial Transcriptomics

Xingzhi Sun, Charles Xu, João Felipe Rocha, Chen Liu, Benjamin Hollander-Bodie, Laney Goldman, Marcello DiStasio, Michael Perlmutter, Smita Krishnaswamy

Abstract: In many data-driven applications, higher-order relationships among multiple objects are essential to capture complex interactions. Hypergraphs, which generalize graphs by allowing edges to connect any number of nodes, provide a flexible and powerful framework for modeling such higher-order relationships. In this work, we introduce hypergraph diffusion wavelets and describe their favorable spectral and spatial properties. We demonstrate their utility for biomedical discovery in spatially resolved transcriptomics by applying the method to represent disease-relevant cellular niches for Alzheimer’s disease.