Abstract: Author summary Resting state fMRI has become a ubiquitous tool for measuring connectivity in normal and diseased brains. Current dominant models of connectivity are based on coarse-scale connectivity among brain regions, ignoring fine-scale structure within those regions. We developed a high-dimensional common model of the human connectome that captures both coarse and fine-scale structure of connectivity shared across brains. We showed that this shared fine-scale structure is related to fine-scale distinctions in representation of information, and our model accounts for substantially more shared variance of connectivity compared to previous models. Our model opens new territory—shared fine-scale structure, a dominant but mostly unexplored component of the human connectome—for analysis and study.
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