DIANA-mirPath: Integrating human and mouse microRNAs in pathways

Giorgos L. Papadopoulos, Panagiotis Alexiou, Manolis Maragkakis, Martin Reczko, Artemis G. Hatzigeorgiou

Abstract: Summary: DIANA-mirPath is a web-based computational tool developed to identify molecular pathways potentially altered by the expression of single or multiple microRNAs. The software performs an enrichment analysis of multiple microRNA target genes comparing each set of microRNA targets to all known KEGG pathways. The combinatorial effect of co-expressed microRNAs in the modulation of a given pathway is taken into account by the simultaneous analysis of multiple microRNAs. The graphical output of the program provides an overview of the parts of the pathway modulated by microRNAs, facilitating the interpretation and presentation of the analysis results.