Abstract: Highlights•A new approach (MINDy) to estimate whole-brain models from resting-state fMRI.•Large-scale models (419 nodes) are fit in under 1 min for individual subjects.•MINDy identifies mechanisms of individual differences.•MINDy predicts individual differences in static and dynamic functional connectivity.•MINDy is reliable and robust to noise, motion, processing choices, and HRF variation.
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