Abstract: Highlights•The RGBNet with ROI embedding outperformed baseline models for the classification of complex medical images.•Statistically, the improvements made by the model are significant, with p-values less than 0.05.•The model performs well across various cancer detection datasets, showing its suitability for different medical scenarios.•Grad-CAM and Guided Grad-CAM visualizations improve interpretability, aiding clinical decision-making.•ROI embedding enhances feature extraction, enabling accurate identification of important regions in complex cases.
External IDs:doi:10.1016/j.rineng.2025.104624
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