Neuronal Spike Shapes (NSS): A straightforward approach to investigate heterogeneity in neuronal excitability states

Lorenzo Martini, Gianluca Amprimo, Stefano Di Carlo, Gabriella Olmo, Claudia Ferraris, Alessandro Savino, Roberta Bardini

Abstract: Highlights•Neuronal heterogeneity underlies brain functional and structural complexity.•Multimodal single-cell data sustain functional and structural analysis of neurons.•NSS captures neuronal excitability states, supporting the study of network dynamics.•NSS-based excitability states support neuronal activity and neuroplasticity studies.