Can We Encode Intra- and Inter-Variability with Log Jacobian Maps Derived from Brain Morphological Deformations Using Pediatric MRI Scans?

Andjela Dimitrijevic, Fanny Dégeilh, Benjamin De Leener

Keywords: Registration, Deformation, Classification, Pediatric

Abstract: Understanding individual variabilities in brain development is crucial for unraveling typical and atypical neurodevelopmental patterns. We propose a novel method using 3D CNN to characterize intra- and inter-individual variability based on log Jacobian maps derived from deformation fields. Inter pairs are chosen to match the distribution of intra pairs based on initial age, age interval (ia\_r experiment) and also sex per pair (ias\_r experiment). Training our model on log Jacobian maps, we explore two scenarios: one with overlaps between train and test sets derived from the same subjects, and the other with no overlaps, using 10-fold cross-validation. While both approaches achieved commendable results, the no overlap scenario showed slightly higher accuracy and F1 score. This research contributes to modeling neurodevelopmental trajectories for future deviation prediction.

Submission Number: 148