Abstract: Wireless capsule endoscopy (WCE) is fundamentally constrained by limited wireless bandwidth, resulting in low imaging resolution and frame rate, which can cause motion blur and missed lesions. Although adaptive frame-rate schemes have been explored to accommodate transient gastrointestinal (GI) motility, these approaches typically require sacrificing image resolution. The use of higher-frequency communication bands is further limited by increased tissue attenuation. To address these challenges, we propose a hybrid Bluetooth Low Energy (BLE) and WiFi communication architecture that combines the low-power operation of BLE with the high data throughput of WiFi. We systematically evaluate the performance of BLE and WiFi under tissue-mimicking conditions by measuring throughput, received signal strength indicator (RSSI), and power consumption. The results demonstrate that amplified BLE with an adaptive transmission power control strategy provides a stable frame rate at low power consumption, while 2.4 GHz WiFi operating in station mode is the most suitable high-throughput communication configuration for WCE. Compared with WiFi, BLE reduces power consumption by approximately ten times, whereas WiFi achieves up to ten times higher throughput. To reconcile these complementary trade-offs, we further introduce a hybrid system with a frame-boundary-synchronized switching mechanism to ensure lossless data transmission during BLE and WiFi transitions. Experimental results show that the switching latency from BLE to WiFi is approximately 92.66 ms, which is longer than the WiFi-to-BLE switching latency of 15.49 ms when transmitting 10 kB image payloads. Overall, the proposed hybrid BLE and WiFi system enables robust, lossless, and energy-efficient mode switching, supports adaptive imaging, and advances the development of next-generation autonomous WCE platforms.
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