SICOR: Subgraph Isomorphism Comparison of RNA Secondary Structures

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Michael Schmidt, Kay Hamacher, Felix Reinhardt, Thea S. Lotz, Florian Groher, Beatrix Suess, Sven Jager

Published: 01 Jan 2020, Last Modified: 13 Nov 2025IEEE ACM Trans. Comput. Biol. Bioinform. 2020EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: RNA aptamer selection during SELEX experiments builds on secondary structural diversity. Advanced structural comparison methods can focus this diversity. We develop SICOR, which uses probabilistic subgraph isomorphisms for graph distances between RNA secondary structure graphs. SICOR outperforms other comparison methods and is applicable to many structural comparisons in experimental design.