A Framework for the generation of digital twins of cardiac electrophysiology from clinical 12-leads ECGs

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Karli Gillette, Matthias A. F. Gsell, Anton J. Prassl, Elias Karabelas, Ursula Reiter, Gert Reiter, Thomas Grandits, Christian Payer, Darko Stern, Martin Urschler, Jason D. Bayer, Christoph M. Augustin, Aurel Neic, Thomas Pock, Edward J. Vigmond, Gernot Plank

Published: 01 Jan 2021, Last Modified: 06 May 2025Medical Image Anal. 2021EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•Model reference frame allowing unattended manipulation of spatiallyvarying parameters.•Comprehensive physiological feature vector of ventricular EP during sinusrhythm.•Fast-forward ECG model producing gold-standard ECGs with real-time performance.•Automated workflow for generation of cardiac digital twins demonstrating feasibility.