The numerical stability of transformation-based CT ventilation

Edward Castillo, Richard Castillo, Yevgeniy Vinogradskiy, Thomas Guerrero

Abstract: Computed tomography (CT)-derived ventilation imaging utilizes deformable image registration (DIR) to recover respiratory-induced tissue volume changes from inhale/exhale 4DCT phases. While current strategies for validating CT ventilation rely on analyzing its correlation with existing functional imaging modalities, the numerical stability of the CT ventilation calculation has not been characterized.