Deep Learning for Classifying Anti-Shigella Opsono- Phagocytosis-Promoting Monoclonal Antibodies

Published: 01 Jan 2024, Last Modified: 26 Feb 2025MOVI@MICCAI 2024EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Shigellosis is an acute small intestine infection caused by different species of Shigella. Worldwide, the emergence of antibiotic-resistant strains aggravates the impact of Shigella infections. In this context, human monoclonal antibodies (mAbs) offer an alternative to traditional antimicrobials. However, identifying a potent candidate mAb requires intense and meticulous efforts. Here, we show the potential of Deep Learning to screen mAbs rapidly. We measured the phagocytosis-promoting activity of mAbs by analyzing images collected with a high-throughput and high-content confocal fluorescence microscope.
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