Automated Oral Epithelial Dysplasia Grading Using Neural Networks and Feature Analysis

Neda Azarmehr, Adam Shephard, Hanya Mahmood, Nasir Rajpoot, Syed Ali Khurram

Keywords: Oral Epithelial Dysplasia, Histopathological Images, Neural Architecture Search, Deep Learning, Machine Learning

TL;DR: Automated Oral Epithelial Dysplasia Grading

Abstract:

Oral epithelial dysplasia (OED) is a precancerous lesion, histologically graded as mild, moderate or severe. The manual histological diagnosis of OED is time-consuming and subjective. We explore a customised Neural Architecture Search (NAS) technique to optimise
an efficient architecture for full epithelium and individual nuclei segmentation in pathology whole slide images (WSIs). Results show the NAS-derived model outperforms all state-of-the-art networks. Accurate nuclear segmentation allows us to extract morphometric
features. We propose a random forest model, using these features, to differentiate between OED grades.

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Paper Type: novel methodological ideas without extensive validation

Primary Subject Area: Application: Histopathology

Secondary Subject Area: Segmentation

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