Learning Interpretable Regularized Ordinal Models from 3D Mesh Data for Neurodegenerative Disease Staging

Yuji Zhao, Max A. Laansma, Eva M. van Heese, Conor Owens-Walton, Laura M. Parkes, Ines Debove, Christian Rummel, Roland Wiest, Fernando Cendes, Rachel Guimaraes, Clarissa Lin Yasuda, Jiun-Jie Wang, Tim J. Anderson, John C. Dalrymple-Alford, Tracy R. Melzer, Toni L. Pitcher, Reinhold Schmidt, Petra Schwingenschuh, Gaëtan Garraux, Mario Rango et al. (22 additional authors not shown)

Abstract: We extend the sparse, spatially piecewise-contiguous linear classification framework for mesh-based data to ordinal logistic regression. The algorithm is intended for use with subcortical shape and cortical thickness data where progressive clinical staging is available, as is generally the case in neurodegenerative diseases. We apply the tool to Parkinson’s and Alzheimer’s disease staging. The resulting biomarkers predict Hoehn-Yahr and cognitive impairment stages at competitive accuracy; the models remain parsimonious and outperform one-against-all models in terms of the Akaike and Bayesian information criteria.