Abstract: Highlights•A framework for robustness evaluation of deep diagnostic models under adversarial attack has been proposed.•A novel benchmark dataset and a robustness evaluation metric are proposed to evaluate the common perturbation robustness of three representative deep diagnostic models.•Two new defense methods are designed to handle adversarial examples in deep diagnostic models, called Multi Perturbations Adversarial Training (MPAdvT) and Misclassification Aware Adversarial Training (MAAdvT) MAAdvT), respectively.•Experimental results have shown that the proposed defense method scan effectively improve the robustness of deep diagnostic models.
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