COP-E-CAT: cleaning and organization pipeline for EHR computational and analytic tasks

Aishwarya Mandyam, Elizabeth C. Yoo, Jeff Soules, Krzysztof Laudanski, Barbara E. Engelhardt

Abstract: In order to ensure that analyses of complex electronic healthcare record (EHR) data are reproducible and generalizable, it is crucial for researchers to use comparable preprocessing, filtering, and imputation strategies. We introduce COP-E-CAT: Cleaning and Organization Pipeline for EHR Computational and Analytic Tasks, an open-source processing and analysis software for MIMIC-IV, a ubiquitous benchmark EHR dataset. COP-E-CAT allows users to select filtering characteristics and preprocess covariates to generate data structures for use in downstream analysis tasks. This user-friendly approach shows promise in facilitating reproducibility and comparability among studies that leverage the MIMIC-IV data, and enhances EHR accessibility to a wider spectrum of researchers than current data processing methods. We demonstrate the versatility of our workflow by describing three use cases: ensemble prediction, reinforcement learning, and dimension reduction. The software is available at: https://github.com/eyeshoe/cop-e-cat.