Abstract: Highlights•We proposed a meta multi-task learning scheme (Meta-MTL) for nuclei segmentation with better domain adaptation and less data dependency.•In the contour-aware multi-task learning model, we proposed a feature fusion and interaction block (FFIB) for features communication between two parallel tasks.•Our proposed model achieves comparable performances with state-of-the-art models with fewer training samples. And the proposed model performs well on domain adaptation and domain generalization.
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