Sex differences in autism spectrum disorder using class imbalance adjusted functional connectivity

Jong Young Namgung, Jongmin Mun, Yeongjun Park, Jaeoh Kim, Bo-yong Park

Abstract: Highlights•Investigated interaction effects between sex and autism condition.•Sex ratio was matched using the Gaussian mixture model-based oversampling.•Low-dimensional principal functional gradients were generated.•Sex-related effects were linked to gene enrichment in cortex, thalamus, and striatum.•Gradients showed varying associations with symptom severity across sexes.