Tissue-specific and interpretable sub-segmentation of whole tumour burden on CT images by unsupervised fuzzy clustering

Leonardo Rundo, Lucian Beer, Stephan Ursprung, Paula Martin-Gonzalez, Florian Markowetz, James D. Brenton, Mireia Crispin-Ortuzar, Evis Sala, Ramona Woitek

Abstract: Highlights•Intelligent two-stage method for CT tissue-specific image segmentation of whole tumours.•Unsupervised fuzzy clustering framework for interpretable sub-segmentation.•Sub-segmentation results achieved on ovarian and renal cancer are accurate and reliable.•The proposed computational framework considerably outperforms conventional approaches.•Insights gained about intra-tumoural heterogeneity evaluation for radiomics.