Associations Between Hippocampal Transverse Relaxation Time and Amyloid PET in Cognitively Normal Aging Adults

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Yu Veronica Sui, Arjun V. Masurkar, Timothy M. Shepherd, Yang Feng, Thomas Wisniewski, Henry Rusinek, Mariana Lazar

Published: 22 Aug 2025, Last Modified: 23 Oct 2025Journal of Magnetic Resonance ImagingEveryoneRevisionsCC BY-SA 4.0
Abstract: Identifying early neuropathological changes in Alzheimer's disease (AD) is important for improving treatment efficacy. Among quantitative MRI measures, transverse relaxation time (T2) has been shown to reflect tissue microstructure relevant in aging and neurodegeneration; however, findings regarding T2 changes in both normal aging and AD have been inconsistent. The association between T2 and amyloid-beta (Aβ) accumulation, a hallmark of AD pathology, is also unclear, particularly in cognitively normal individuals who may be in preclinical stages of the disease.