Abstract: Highlights•We present an approach for achieving availability and performance when deploying web applications in distributed Clouds.•A genetic algorithm for data center (DC) selection that factors in proximity to users and inter-DC latencies is presented.•This work focuses on the placement issue and improves end-to-end response times even in the presence of failures.•We show how latency-aware application deployment can offer higher performance and stability before and after failures.•We present results based on realistic Cloud-based experiments across the national research Cloud in Australia.
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