FDDM: Frequency-Decomposed Diffusion Model for Dose Prediction in Radiotherapy

Xin Liao, Zhenghao Feng, Jianghong Xiao, Xingchen Peng, Yan Wang

Abstract: Accurate dose distribution prediction is crucial in the radiotherapy planning. Although previous methods based on convolutional neural network have shown promising performance, they have the problem of over-smoothing, leading to prediction without important high-frequency details. Recently, diffusion model has achieved great success in computer vision, which excels in generating images with more high-frequency details, yet suffers from time-consuming and extensive computational resource consumption. To alleviate these problems, we propose Frequency-Decomposed Diffusion Model (FDDM) that refines the high-frequency subbands of the dose map. To be specific, we design a Coarse Dose Prediction Module (CDPM) to first predict a coarse dose map and then utilize 2D discrete wavelet transform to decompose the coarse dose map into a low-frequency subband and three high-frequency subbands. There is a notable difference between the coarse predicted results and ground truth in high-frequency subbands. Therefore, we design a diffusion-based module called High-Frequency Refinement Module (HFRM) that performs diffusion operation in the high-frequency components of the dose map instead of the original dose map. Extensive experiments on two in-house datasets verify the effectiveness of our approach.