Multi-source data integration for explainable miRNA-driven drug discovery

Zhen Li, Qingquan Liao, Wenbin Liu, Peng Xu, Linlin Zhuo, Xiangzheng Fu, Quan Zou

Abstract: Highlights•This study presents an explainable model for miRNA-driven drug discovery.•The introduced similarity fusion technique improves the initial representations.•The model employs subgraph estimation to mitigate the risk of “overfitting”.•Incorporating a global attention to uncover unknown miRNA–disease dependencies.