Interactive Cell Detection in H&E-stained slides of Diffuse Gastric Cancer

Robin Lomans, Rachel van der Post, Francesco Ciompi

Keywords: Interactive detection, signet ring cells, diffuse gastric cancer, interactive annotation

TL;DR: We present an interactive detection model to substantially reduce the effort required for multi-class cell annotation in diffuse gastric cancer

Abstract:

We present an interactive detection model to improve the cell annotation workflow of diffuse gastric cancer.
The model relates image and user inputs and is trained to detect three types of cells in diffuse gastric cancer histology.
We measure model multi-class cell detection performance as per-class F1 score and we show that it increases with the number of user input clicks.
Moreover, we show that the proposed interactive annotation approach substantially reduces the number of required user actions needed for complete image annotation, achieving a 17% reduction for the multi-class case.
Future work will implement an iterative approach to filter out recurring false positives for further performance improvement.