Weakly supervised lesion localization and attribution for OCT images with a guided counterfactual explainer model

Limai Jiang, Ruitao Xie, Bokai Yang, Juan He, Huazhen Huang, Yi Pan, Yunpeng Cai

Abstract: Highlights•OCT-CAE disentangles class-related and -irrelevant information for precise lesion localization.•Achieves state-of-the-art performance on two public OCT image datasets.•Generates accurate saliency maps and visualizes feature transitions within the manifold.•Superior in producing realistic pseudo-healthy images and class conversion.