HelixFold-Single: MSA-free Protein Structure Prediction by Using Protein Language Model as an Alternative

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Xiaomin Fang, Fan Wang, Lihang Liu, Jingzhou He, Dayong Lin, Yingfei Xiang, Xiaonan Zhang, Hua Wu, Hui Li, Le Song

Published: 15 Sept 2022, Last Modified: 07 Jan 2026CrossrefEveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: AI-based protein structure prediction pipelines, such as AlphaFold2, have achieved near-experimental accuracy. These advanced pipelines mainly rely on Multiple Sequence Alignments (MSAs) as inputs to learn the co-evolution information from the homologous sequences. Nonetheless, searching MSAs fro...