Acceleratingsaturation mutagenesis using compressed sensing

Jacob M. Schreiber, Surag Nair, Akshay Balsubramani, Anshul Kundaje

Abstract: In silico saturation mutagenesis (ISM) is a popular approach in computational genomics for calculating feature attributions on biological sequences that proceeds by systematically perturbing each position in a sequence and recording the difference in model output. However, this method can be slow because systematically perturbing each position requires performing a number of forward passes proportional to the length of the sequence being examined.