Abstract: Multi-Modal image registration is the primary step in fusing complementary information contained in different imaging modalities for diagnostic purposes. We focus on two specific retinal imaging modalities namely, Color Fundus Image(CFI) and Fluroscein Fundus Angiogram(FFA). In this paper we investigate a projection based method using Radon transform for accurate matching in multi-modal retinal images. A novel Radon Transform based descriptor is proposed, which is invariant to illumination, rotation and partially to scale. Our results show that our descriptor is well suited for retinal images as it is robust to lesions, and works well even in poor quality images. The descriptor has been tested on a dataset of 126 images and compared for matching application against gradient based descriptors. The results show that Radon based descriptor outperforms the gradient based ones in both being able to discriminate between true and false matches and under presence of lesions.
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