Toward Automatic Tumor-Stroma Ratio Assessment for Survival Analysis in Colorectal Cancer

Christian Abbet, Linda Studer, Inti Zlobec, Jean-Philippe Thiran

Keywords: Computational pathology, tumor-stroma ratio, colorectal cancer

TL;DR: We present a fully automated system for TSR scoring in line with current recommendations for pathologists, based on tumor and tumor-adjacent stroma tissue detection.

Abstract:

In this paper, we present a fully automated system for tumor-stroma ratio scoring in line with current recommendations for pathologists, based on tumor and tumor-adjacent stroma tissue detection.
In order to evaluate the scoring system, we perform survival analysis on 221 whole slide images from colorectal cancer patients.
We find that the whole slide-level and region of interest-level tumor-stroma ratio are statistically significant predictors of overall survival.

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Paper Type: recently published or submitted journal contributions

Primary Subject Area: Application: Histopathology

Secondary Subject Area: Detection and Diagnosis

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