Multi-View Adaptive Fusion Network for Spatially Resolved Transcriptomics Data Clustering

Yanran Zhu, Xiao He, Chang Tang, Xinwang Liu, Yuanyuan Liu, Kunlun He

Abstract: Spatial transcriptomics technology fully leverages spatial location and gene expression information for spatial clustering tasks. However, existing spatial clustering methods primarily concentrate on utilizing the complementary features between spatial and gene expression information, while overlooking the discriminative features during the integration process. Consequently, the discriminative capability of node representation in the gene expression features is limited. Besides, most existing methods lack a flexible combination mechanism to adaptively integrate spatial and gene expression information. To this end, we propose an end-to-end deep learning method named MAFN for spatially resolved transcriptomics data clustering via a multi-view adaptive fusion network. Specifically, we first adaptively learn inter-view complementary features from spatial and gene expression information. To improve the discriminative capability of gene expression nodes by utilizing spatial information, we employ two GCN encoders to learn intra-view specific features and design a Cross-view Correlation Reduction (CCR) strategy to filter the irrelevant information. Moreover, considering the distinct characteristics of each view, a Cross-view Attention Module (CAM) is utilized to adaptively fuse the multi-view features. Extensive experimental results demonstrate that the proposed MAFN achieves competitive performance in spatial domain identification compared to other state-of-the-art ones.