Clinical Risk-Aware Multi-Level Grading for Coronary Artery Stenosis through Curved Feature Reconstruction

Shishuang Zhao, Li Hongtai, Junjie Hou, Yuhang Liu

Keywords: Multi-level stenosis grading, Deep learning, CCTA, 3D SCPR

TL;DR: This paper proposes a novel framework for multi-level coronary artery stenosis grading that uses a Curved Feature Reconstruction module to fuse CCTA and 3D SCPR images and a Clinical Risk-Aware Loss to align the model with clinical risk boundaries.

Abstract: Developing a multi-level grading model for coronary artery stenosis holds great clinical significance for the diagnosis of coronary artery disease. However, designing an effective multi-level deep learning algorithm faces significant challenges. Specifically, utilizing CCTA or 3D SCPR images alone presents inherent shortcomings: CCTA images are difficult to analyze due to the tortuous paths of blood vessels, while 3D SCPR images are prone to abnormal distortions that hinder accurate grading. Furthermore, different stenosis grades are associated with varying clinical risks, and incorporating this association into the algorithm is non-trivial. To address the former problems, we propose the Curved Feature Reconstruction (CFR) module, which uses vessel curves as prior and employs a point-by-point correspondence strategy to precisely align and fuse features from both 3D SCPR and CCTA images. Meanwhile, a Clinical Risk-Aware (CR) Loss is employed to introduce clinical risk relevance into the network training so that the algorithm can better align with the clinical diagnosis. The experimental results on a in-house dataset reveal that our approach significantly outperforms other methods, and several ablation studies also demonstrate the effectiveness of our proposed designs.

Primary Subject Area: Application: Cardiology

Secondary Subject Area: Detection and Diagnosis

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LLM Policy: Yes

Submission Number: 191