Abstract: Based on two-domain DNA strand displacement, a computing model is proposed. The model is used as a “referee” for two players in a well-known Rock-Paper-Scissors game, which can be utilized as an example of the study of game theory and artificial intelligence (AI). A molecular model based on Two-domain strand displacement is applied to emulate the process of the game. The output of the circuit shows the final result of the underlying game, that is, each player’s win, lose and draw. The two players hold a win of one inning and two win of three innings which are simulated by employing Visual DSD software. The simulation results show that the molecular model is correct and feasible. The establishment of the computing model is hoped to provide some new insights for the AI in the field of nanotechnology.
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