Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

Yingtian Pan, Jiang You, Nora D. Volkow, Kicheon Park, Congwu Du

Abstract: Highlights•Quantitative imaging of flow velocities in capillary networks, not isolated vessels•Image CBF dynamics at high spatiotemporal resolutions and over a large field of view•Complement fMRI and TPM for studying heterogeneous CBF response to brain stimulations•Quantify ultraslow flows of a brain tumor and ischemic mouse brain by chronic cocaine exposure