Altered dynamics of T cell subsets in peripheral blood impacts disease progression in newly diagnosed multiple myeloma

Mohini Vig, Lalit Kumar, Shweta Dubey, Ritu Gupta

Abstract: Highlights•NDMM patients display decreased number of T-cells and altered balance of naïve and memory T cell subsets.•Disturbed equilibrium of naïve and memory Tregs is a key characteristic of NDMM patients.•Activated follicular helper T cells correlate with increased bone marrow plasma cells in NDMM.•Elevated levels of CD160, ICOS, CTLA-4, and PD-1 on T cells, along with their correlation to bone marrow plasma cells, indicate immune-driven disease progression in NDMM.•These T-cell abnormalities may be considered to harness the benefits of immunotherapy in NDMM.

External IDs:doi:10.1016/j.bbrep.2025.102104