Abstract: The rise of Artificial Intelligence for Science (AI4S) has highlighted the importance and urgency of ensuring open-ness, fairness, impartiality, diversity, and sustainability in scientific systems. Existing scientific systems, referred to as Centralized Science (CeSci), are built on centralized organizational structures and top-down institutional frameworks, which are lagging behind the development and practical requirements of AI4S. To address these limitations, AI4S needs to embrace a new scientific organizational and operational paradigm, namely Decentralized Science (DeSci). It can provide strong support to AI4S via effectively addressing issues such as information silos, biases, unfair distribution, and monopolies and promoting multidisciplinary, interdisciplinary, and trans disciplinary cooperation in science. Based on these considerations, this paper presents the framework of AI4S based on DeSci and explores its potential application scenarios and research issues. The research can provide effective guidance for the development of scientific systems.
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