Toward a Semantic Framework for the Querying, Mining and Visualization of Cancer Microenvironment Data

Michelangelo Ceci, Fabio Fumarola, Pietro Hiram Guzzi, Federica Mandreoli, Riccardo Martoglia, Elio Masciari, Massimo Mecella, Wilma Penzo

Abstract: Over the last decade, the advances in the high-throughput omic technologies have given the possibility to profile tumor cells at different levels, fostering the discovery of new biological data and the proliferation of a large number of bio-technological databases. In this paper we describe a framework for enabling the interoperability among different biological data sources and for ultimately supporting expert users in the complex process of extraction, navigation and visualization of the precious knowledge hidden in such a huge quantity of data. The system will be used in a pilot study on the Multiple Myeloma (MM).