Deep Local Analysis deconstructs protein-protein interfaces and accurately estimates binding affinity changes upon mutation

Yasser Mohseni Behbahani, Elodie Laine, Alessandra Carbone

Abstract: The spectacular recent advances in protein and protein complex structure prediction hold promise for reconstructing interactomes at large-scale and residue resolution. Beyond determining the 3D arrangement of interacting partners, modeling approaches should be able to unravel the impact of sequence variations on the strength of the association.